Time to re-evaluate the risks and benefits of valproate and a call for action.
Howes OD., Barnes TRE., Lennox BR., Markham S., Natesan S.
Valproate is widely used in psychiatry and neurology, including off-label use. Here we consider its potential benefits and risks, particularly for women of childbearing potential, and the evidence that clinical guidelines are adhered to. Finally, we consider the implications for clinical practice and research into its efficacy in off-label indications.