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BACKGROUND: Diagnostic classes (derived from CATEGO) can be correlated with regional brain metabolism in patients with major psychiatric disorders. METHOD: Seventeen patients with schizophrenia, 15 with mania, 10 with depression and 10 healthy Volunteers were examined with positron emission tomography (PET) and 18F-labelled fluorodeoxyglucose, as a marker for glucose metabolism. The number of possible comparisons of regions of interest was reduced by principal-components analysis, and differences in factor scores were determined between diagnostic groups. RESULTS: Four independent factors, representing distributed brain systems, emerged: an anterior-posterior (1), a left-right temporal (2), a temporofrontal (3), and a mediofrontal (4) system, of which (1), (2) and (3) were abnormal in schizophrenia, (1) and (2) in mania, and (1) in depression. CONCLUSIONS: Abnormal patterns of metabolism could be detected, in decreasing order, in schizophrenia, mania and depression. Some of these abnormalities are likely to be due to medication, but others will be associated with structural or functional abnormalities of the frontolimbic system in the diagnostic groups.

Original publication




Journal article


Br J Psychiatry

Publication Date





509 - 516


Adult, Aged, Bipolar Disorder, Blood Glucose, Brain Mapping, Deoxyglucose, Depressive Disorder, Dominance, Cerebral, Energy Metabolism, Female, Fluorodeoxyglucose F18, Humans, Image Processing, Computer-Assisted, Limbic System, Male, Middle Aged, Reference Values, Schizophrenia, Tomography, Emission-Computed