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Lombardi et al. (Reports, 23 October 2009, p. 585) reported a significant association between the human retrovirus XMRV and chronic fatigue syndrome (CFS). However, the cases with CFS and the control subjects in their study are poorly described and unlikely to be representative. Independent replication is a critical first step before accepting the validity of this finding


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Association, Australia, blood, Blood Cells, case, Case-Control Studies, CFS, control, Epidemiologic Research Design, etiology, fatigue, Fatigue Syndrome,Chronic, Gammaretrovirus, Human, Humans, infection, Inflammation, isolation & purification, New South Wales, patient, Patients, Reproducibility of Results, research, Retroviridae Infections, retrovirus, syndrome, Tumor Virus Infections, Universities, validity, virology, Wales