Cookies on this website

We use cookies to ensure that we give you the best experience on our website. If you click 'Accept all cookies' we'll assume that you are happy to receive all cookies and you won't see this message again. If you click 'Reject all non-essential cookies' only necessary cookies providing core functionality such as security, network management, and accessibility will be enabled. Click 'Find out more' for information on how to change your cookie settings.

Near infrared spectroscopy (NIRS) is used to measure CBF (CBFNIRS) in humans, based on Fick's principle, using oxygen as an intravascular tracer. We compared CBFNIRS with CBF measured by microspheres (CBF mu) and the venous outflow technique (CBFv) in 15 dogs, altering CBF with ventilation-induced changes in PaCO2. Five hundred forty-nine CBFNIRS measurements were attempted using an integration time of 2.5 s on the saturation signal from the tongue. One hundred ninety-eight (36.1%) of the measurements fulfilled predefined criteria. The coefficient of variation (CV) for six measurements under stable conditions was 29.1%. The CBFNIRS measurements correlated best with microsphere-measured blood flows in the cortical gray matter (median 0.43, range 0.16-0.93); the contributions of the skull and dura were variable. The CBFv varied by a médian of 12% (range 0-67%) during the CBFNIRS measurements. The percentage of acceptable CBFNIRS measurements, the CV, and the correlation coefficients of the CBFNIRS were improved by using saturation signal directly from the artery and varying the integration time with an estimate of the minimum transit time. The current method of measuring CBFNIRS in the reflectance mode is in-accurate when compared with other accepted techniques.

Original publication

DOI

10.1097/00004647-199706000-00011

Type

Journal article

Journal

J Cereb Blood Flow Metab

Publication Date

06/1997

Volume

17

Pages

695 - 703

Keywords

Animals, Carbon Dioxide, Cerebrovascular Circulation, Dogs, Hemoglobins, Hypoxia, Linear Models, Male, Microspheres, Oxyhemoglobins, Reproducibility of Results, Spectroscopy, Near-Infrared