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The effects of a novel antidepressant, nefazodone (50 mg, 100 mg, and 200 mg orally) on neuroendocrine function and temperature were assessed using a single-blind, crossover design in eight healthy male volunteers. Nefazodone significantly increased plasma levels of prolactin (PRL) and raised oral temperature. There was also a trend towards an increase in plasma cortisol. These results are consistent with an acute facilitatory effect of some aspects of 5-HT neurotransmission, perhaps mediated through nefazodone's metabolism to its major metabolite, m-chlorophenylpiperazine (mCPP).


Journal article


Biol Psychiatry

Publication Date





115 - 119


Adrenocorticotropic Hormone, Adult, Antidepressive Agents, Body Temperature, Dose-Response Relationship, Drug, Humans, Hydrocortisone, Male, Middle Aged, Placebos, Prolactin, Single-Blind Method, Triazoles