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We studied the effect of the α2‐adrenoceptor agonist, clonidine, and bright artificial light (>2500 lux) on the nocturnal increase in plasma melatonin in normal subjects. Clonidine (1.5 μg/kg, intravenously) was without effect on plasma melatonin concentration. In contrast, bright light treatment abolished the increase in night‐time melatonin. Bright light is a simple and effective means of altering melatonin secretion in humans. Copyright © 1988 John Wiley & Sons, Ltd.

Original publication




Journal article


Human Psychopharmacology: Clinical and Experimental

Publication Date





43 - 46