MAOA: Association and linkage studies with lithium responsive bipolar disorder
Turecki G., Grof P., Cavazzoni P., Duffy A., Grof E., Ahrens B., Berghöfer A., Müller-Oerlinghausen B., Dvoráková M., Libigerová E., Vojtechovsky M., Zvolsky P., Joober R., Nilsson A., Prochazka H., Licht RW., Rasmussen NA., Schou M., Vestergaard P., Holzinger A., Schumann C., Thau K., Rouleau GA., Alda M.
A number of association studies have investigated the role of the monoamine oxidase A (MAOA) gene in the susceptibility to bipolar disorder. Although some studies have reported positive findings, there remains some controversy, because results from different studies have not been consistent. A common explanation for inconsistencies between studies is genetic heterogeneity. We have focused on lithium responsive bipolar disorder as a wag to reduce heterogeneity. In this study, we investigated the role of MAOA in lithium responsive bipolar patients using association and linkage study designs. The investigation used 138 patients and 108 normal controls. In addition, 25 families were also studied. Our results were not supportive of a major role of MAOA in the predisposition to bipolar disorder.