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BACKGROUND: People with prodromal symptoms have a very high risk of developing psychosis. AIMS: To use functional magnetic resonance imaging to examine the neurocognitive basis of this vulnerability. METHOD: Cross-sectional comparison of regional activation in individuals with an'at-risk mental state' (at-risk group: n=17), patients with first-episode schizophreniform psychosis (psychosis group: n=10) and healthy volunteers (controls: n=15) during an overt verbal fluency task and an N-back working memory task. RESULTS: A similar pattern of between-group differences in activation was evident across both tasks. Activation in the at-risk group was intermediate relative to that in controls and the psychosis group in the inferior frontal and anterior cingulate cortex during the verbal fluency task and in the inferior frontal, dorsolateral prefrontal and parietal cortex during the N-back task. CONCLUSIONS: The at-risk mental state is associated with abnormalities of regional brain function that are qualitatively similar to, but less severe than, those in patients who have recently presented with psychosis.

Original publication

DOI

10.1192/bjp.bp.107.046789

Type

Journal article

Journal

Br J Psychiatry

Publication Date

01/2009

Volume

194

Pages

25 - 33

Keywords

Adult, Case-Control Studies, Cross-Sectional Studies, Female, Gyrus Cinguli, Humans, Magnetic Resonance Imaging, Male, Memory Disorders, Neuropsychological Tests, Psychotic Disorders, Risk Factors, Schizophrenia, Treatment Outcome, Verbal Behavior, Young Adult