Cookies on this website
We use cookies to ensure that we give you the best experience on our website. If you click 'Continue' we'll assume that you are happy to receive all cookies and you won't see this message again. Click 'Find out more' for information on how to change your cookie settings.

Cerebrovascular disease (CVD) and amyloid burden are the most frequent pathologies in subjects with cognitive impairment. However, the relationship between CVD, amyloid burden, and cognition are largely unknown. We aimed to evaluate whether CVD (lacunes, white matter hyperintensities, and microbleeds) and amyloid burden (Pittsburgh compound B [PiB] retention ratio) contribute to cognitive impairment independently or interactively. We recruited 136 patients with subcortical vascular cognitive impairment who underwent magnetic resonance imaging, PiB-positron emission tomography, and neuropsychological testing. The number of lacunes was associated with memory, frontal dysfunctions, and disease severity. The volume of white matter hyperintensities and the PiB retention ratio were associated only with memory dysfunction. There was no direct correlation between CVD markers and PiB retention ratio except that the number of lacunes was negatively correlated with the PiB retention ratio. In addition, there were no interactive effects of CVD and PiB retention ratio on cognition. Our findings suggest that CVD and amyloid burden contribute independently and not interactively to specific patterns of cognitive dysfunction in patients with subcortical vascular cognitive impairment.

Original publication

DOI

10.1016/j.neurobiolaging.2013.06.026

Type

Journal article

Journal

Neurobiol Aging

Publication Date

01/2014

Volume

35

Pages

254 - 260

Keywords

Amyloid, Cerebrovascular disease, Cognition, Lacune, Microbleed, Pittsburgh compound B, White matter hyperintensity, Aged, Aged, 80 and over, Amyloid beta-Peptides, Aniline Compounds, Brain, Cerebrovascular Disorders, Cognition Disorders, Female, Humans, Magnetic Resonance Imaging, Male, Memory Disorders, Neuropsychological Tests, Positron-Emission Tomography, Thiazoles