Cellular and molecular regulation of eosinophil trafficking to the lung.
Hogan SP., Mould AW., Young JM., Rothenberg ME., Ramsay AJ., Matthaei K., Young IG., Foster PS.
Airway inflammation is central to the pathogenesis of allergic asthma, and molecules that mediate this process obviously represent targets for therapy. In the present article, we discuss our experiments, which point to CD4+ T cells and IL-5-driven eosinophilia as potential targets for the relief of bronchial hyperreactivity in late-phase asthma.