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BACKGROUND: Increased arterial stiffness predicts future cardiovascular disease and in some cross-sectional studies it is related to worse lung function and obstructive pulmonary disease. We assessed the predictive value of lung function measured in mid-life as compared with later life on arterial stiffness in the Caerphilly Prospective Study (CaPS). METHODS: Men aged 47-67 years had lung function measured between 1984 and 1988 and repeated between 2002 and 2004 (n = 827) as well as having carotid-femoral pulse wave velocity (PWV) measured. RESULTS: Both forced expiratory volume in 1 s (FEV(1)) and forced vital capacity (FVC) in mid-life and later life were inversely associated with PWV (P < 0.0001) but mid-life measures were stronger predictors. Only mid-life measures remained predictors after mutual adjustment (FEV(1) mid-life beta coeff. -0.65, 95% CI -1.04, -0.26, P < 0.0001; FVC mid-life beta coeff. -0.52, 95% CI -0.82, -0.23, P < 0.0001). Adjustment for smoking status, early life, inflammatory and metabolic factors in sub-groups did not markedly change the associations. CONCLUSIONS: Mid-life lung function is a stronger risk factor than in later life for arterial stiffness in men. It is possible that developmental factors influence both lung function and arterial stiffness. Lung function assessment in mid-life may identify individuals at greater risk of their future cardiovascular disease.

Original publication

DOI

10.1093/ije/dyn374

Type

Journal article

Journal

Int J Epidemiol

Publication Date

06/2009

Volume

38

Pages

867 - 876

Keywords

Aged, Cardiovascular Diseases, Coronary Vessels, Elasticity, Forced Expiratory Volume, Humans, Lung Diseases, Male, Middle Aged, Predictive Value of Tests, Prospective Studies, Respiratory Function Tests, Socioeconomic Factors, Vital Capacity, Wales