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Alzheimer's disease is the scourge of the modern, aging world: a costly, damaging disease that robs the elderly of their ability to function as well as their memories. Three decades of progress have resulted in a deep understanding of the pathological processes and a range of targets for therapy, many of which have advanced to late-stage clinical trials. Proteomics has contributed greatly to these advances and will continue to have a growing role in determining the nature of the pathological lesions in the brain. In addition, proteomics (both gel based and gel free, mass spectrometry based), is likely to play an increasing role in identifying biomarkers that may assist in early diagnosis and in monitoring progression and, most importantly, response to therapy.

Original publication

DOI

10.1586/14789450.4.2.227

Type

Journal article

Journal

Expert Rev Proteomics

Publication Date

04/2007

Volume

4

Pages

227 - 238

Keywords

Alzheimer Disease, Amyloid beta-Peptides, Biomarkers, Electrophoresis, Gel, Two-Dimensional, Humans, Mass Spectrometry, Protein Binding, Proteomics