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There is evidence of genetic and neural system overlap in Autism Spectrum Disorder (ASD) and Early Psychosis (EP). Five datasets were pooled to compare mu suppression index (MSI), a proxy of mirror neuron activity, in EP, high functioning ASD, and healthy subjects (HS). ASDs and EPs with "active" negative symptoms showed significant differences in mu suppression, in response to Biological Motion/point-light display animation, compared to HS. Preliminary findings suggest that similar neural network deficits in ASD and EP could be driven by the expression of negative symptoms in the latter group of patients. These findings may aid future studies on EP and ASD and facilitate the formulation of new hypotheses regarding their pathophysiology.

Original publication




Journal article


Psychiatry Res

Publication Date





374 - 377


Biological Motion, Early Psychosis, Mirror neurons, Negative symptoms, Posterior superior temporal sulcus, Adult, Autism Spectrum Disorder, Case-Control Studies, Electroencephalography, Female, Humans, Male, Middle Aged, Mirror Neurons, Psychotic Disorders