Arne Mould

• Lhx1 functions together with Otx2, Foxa2, and Ldb1 to govern anterior mesendoderm, node, and midline development.

  Costello I. et al, (2015), Genes Dev, 29, 2108 - 2122

• Blimp1/Prdm1 Functions in Opposition to Irf1 to Maintain Neonatal Tolerance during Postnatal Intestinal Maturation.

  Mould AW. et al, (2015), PLoS Genet, 11

• Smchd1 regulates a subset of autosomal genes subject to monoallelic expression in addition to being critical for X inactivation.

  Mould AW. et al, (2013), Epigenetics Chromatin, 6

• The nonconventional MHC class II molecule DM governs diabetes susceptibility in NOD mice.

  Morgan MA. et al, (2013), PLoS One, 8

• Blimp1/Prdm1 governs terminal differentiation of endovascular trophoblast giant cells and defines multipotent progenitors in the developing placenta.

  Mould A. et al, (2012), Genes Dev, 26, 2063 - 2074

• Alternative splicing regulates Prdm1/Blimp-1 DNA binding activities and corepressor interactions.

  Morgan MA. et al, (2012), Mol Cell Biol, 32, 3403 - 3413

• Brca1 is involved in establishing murine pigmentation in a p53 and developmentally specific manner.

  Tonks ID. et al, (2012), Pigment Cell Melanoma Res, 25, 530 - 532

• Brca1 is involved in establishing murine pigmentation in a p53 and developmentally specific manner

  Tonks ID. et al, (2012), Pigment Cell and Melanoma Research, 25, 530 - 532

• Menin and p53 have non-synergistic effects on tumorigenesis in mice.

  Loffler KA. et al, (2012), BMC Cancer, 12

• The transcriptional repressor Blimp1/Prdm1 regulates postnatal reprogramming of intestinal enterocytes.

  Harper J. et al, (2011), Proc Natl Acad Sci U S A, 108, 10585 - 10590

• Alterations in gene expression in MEN1-associated insulinoma development.

  Serewko-Auret MM. et al, (2010), Pancreas, 39, 1140 - 1146

• Melanocyte homeostasis in vivo tolerates Rb1 loss in a developmentally independent fashion.

  Tonks ID. et al, (2010), Pigment Cell Melanoma Res, 23, 564 - 570

• Dual loss of rb1 and Trp53 in the adrenal medulla leads to spontaneous pheochromocytoma.

  Tonks ID. et al, (2010), Neoplasia, 12, 235 - 243

• Dual loss of Rb1 and Trp53 in melanocytes perturbs melanocyte homeostasis and genetic stability in vitro but does not cause melanoma or pigmentation defects in vivo.

  Tonks ID. et al, (2009), Pigment Cell Melanoma Res, 22, 328 - 330

• Global expression profiling of sex cord stromal tumors from Men1 heterozygous mice identifies altered TGF-beta signaling, decreased Gata6 and increased Csf1r expression.

  Mould AW. et al, (2009), Int J Cancer, 124, 1122 - 1132

• Identification of ARHGEF17, DENND2D, FGFR3, and RB1 mutations in melanoma by inhibition of nonsense-mediated mRNA decay.

  Bloethner S. et al, (2008), Genes Chromosomes Cancer, 47, 1076 - 1085

• Prophylactic but not therapeutic activity of a monoclonal antibody that neutralizes the binding of VEGF-B to VEGFR-1 in a murine collagen-induced arthritis model.

  Mould AW. et al, (2008), Rheumatology (Oxford), 47, 263 - 266

• Global expression profiling of murine MEN1-associated tumors reveals a regulatory role for menin in transcription, cell cycle and chromatin remodelling.

  Mould AW. et al, (2007), Int J Cancer, 121, 776 - 783

• Lack of augmentation of tumor spectrum or severity in dual heterozygous Men1 and Rb1 knockout mice.

  Loffler KA. et al, (2007), Oncogene, 26, 4009 - 4017

• Transgenic overexpression of vascular endothelial growth factor-B isoforms by endothelial cells potentiates postnatal vessel growth in vivo and in vitro.

  Mould AW. et al, (2005), Circ Res, 97, e60 - e70

• Melanocytes in conditional Rb-/- mice are normal in vivo but exhibit proliferation and pigmentation defects in vitro.

  Tonks ID. et al, (2005), Pigment Cell Res, 18, 252 - 264

• Tyrosinase-Cre mice for tissue-specific gene ablation in neural crest and neuroepithelial-derived tissues.

  Tonks ID. et al, (2003), Genesis, 37, 131 - 138

• Vegfb gene knockout mice display reduced pathology and synovial angiogenesis in both antigen-induced and collagen-induced models of arthritis.

  Mould AW. et al, (2003), Arthritis Rheum, 48, 2660 - 2669

• Elemental signals regulating eosinophil accumulation in the lung.

  Foster PS. et al, (2001), Immunol Rev, 179, 173 - 181

• Early pregnancy factor suppresses experimental autoimmune encephalomyelitis induced in Lewis rats with myelin basic protein and in SJL/J mice with myelin proteolipid protein peptide 139-151.

  Zhang B. et al, (2000), J Neurol Sci, 182, 5 - 15

• The effect of IL-5 and eotaxin expression in the lung on eosinophil trafficking and degranulation and the induction of bronchial hyperreactivity.

  Mould AW. et al, (2000), J Immunol, 164, 2142 - 2150

• Mice lacking the vascular endothelial growth factor-B gene (Vegfb) have smaller hearts, dysfunctional coronary vasculature, and impaired recovery from cardiac ischemia.

  Bellomo D. et al, (2000), Circ Res, 86, E29 - E35

• Cellular and molecular regulation of eosinophil trafficking to the lung.

  Hogan SP. et al, (1998), Immunol Cell Biol, 76, 454 - 460

• Aeroallergen-induced eosinophilic inflammation, lung damage, and airways hyperreactivity in mice can occur independently of IL-4 and allergen-specific immunoglobulins.

  Hogan SP. et al, (1997), J Clin Invest, 99, 1329 - 1339

• Relationship between interleukin-5 and eotaxin in regulating blood and tissue eosinophilia in mice.

  Mould AW. et al, (1997), J Clin Invest, 99, 1064 - 1071

• The Transcriptional Repressor Blimp1/Prdm1 Expressed in Rare Luminal Progenitors Is Essential for Mammary Gland Development

  Ahmed MIA. et al, Development

• Single-cell RNA-seq reveals cell type-specific transcriptional signatures at the maternal-foetal interface during pregnancy

  Nelson AC. et al, Nature Communications

Recent Publications

• Lhx1 functions together with Otx2, Foxa2, and Ldb1 to govern anterior mesendoderm, node, and midline development.

  Costello I. et al, (2015), Genes Dev, 29, 2108 - 2122
• Blimp1/Prdm1 Functions in Opposition to Irf1 to Maintain Neonatal Tolerance during Postnatal Intestinal Maturation.

  Mould AW. et al, (2015), PLoS Genet, 11
• Smchd1 regulates a subset of autosomal genes subject to monoallelic expression in addition to being critical for X inactivation.

  Mould AW. et al, (2013), Epigenetics Chromatin, 6
• The nonconventional MHC class II molecule DM governs diabetes susceptibility in NOD mice.

  Morgan MA. et al, (2013), PLoS One, 8
• Blimp1/Prdm1 governs terminal differentiation of endovascular trophoblast giant cells and defines multipotent progenitors in the developing placenta.

  Mould A. et al, (2012), Genes Dev, 26, 2063 - 2074