Ivan Koychev
PhD MRCPsych
Senior Clinical Researcher
- Clinician Scientist Dementias Platform UK
- Consultant Neuropsychiatrist Oxford University Hospitals NHS Foundation Trust
I am a clinical academic psychiatrist (on the GMC Specialist Register for Old Age and General Adult Psychiatry) with a focus on the development of treatments for neuropsychiatric disorders. My research experience spans the key components of neuroscience clinical trial methodology: conduct of proof-of-concept (PoC) biomarker-based clinical trials in surrogate populations, testing of repurposed compounds, development of stratification and efficacy biomarkers and creation of infrastructure for large-scale stratified recruitment into neuroscience experimental medicine studies and clinical trials. Clinically, I have focus on the assessment and management of patients with neuropsychiatric presentations in acute medical settings.
Key publications
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Imaging Aβ and tau in early stage Alzheimer's disease with [18F]AV45 and [18F]AV1451.
Journal article
Firouzian A. et al, (2018), EJNMMI Res, 8
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Effects of Acute Ketamine Infusion on Visual Working Memory: Event-Related Potentials.
Journal article
Koychev I. et al, (2017), Biol Psychiatry Cogn Neurosci Neuroimaging, 2, 253 - 262
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PET Tau and Amyloid-β Burden in Mild Alzheimer's Disease: Divergent Relationship with Age, Cognition, and Cerebrospinal Fluid Biomarkers.
Journal article
Koychev I. et al, (2017), J Alzheimers Dis, 60, 283 - 293
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The effect of sodium nitroprusside on psychotic symptoms and spatial working memory in patients with schizophrenia: a randomized, double-blind, placebo-controlled trial.
Journal article
Stone JM. et al, (2016), Psychological medicine, 46, 3443 - 3450
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Visual information processing deficits as biomarkers of vulnerability to schizophrenia: an event-related potential study in schizotypy.
Journal article
Koychev I. et al, (2010), Neuropsychologia, 48, 2205 - 2214
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Cognitive-behavioural therapy for non-motor symptoms of Parkinson's disease: a clinical review.
Journal article
Koychev I. and Okai D., (2017), Evidence-based mental health, 20, 15 - 20
Recent publications
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Dementias Platform UK Clinical Studies and Great Minds Register: protocol of a targeted brain health studies recontact database.
Journal article
Koychev I. et al, (2020), BMJ Open, 10
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Blood-Based ATN Biomarkers of Alzheimer's Disease: A Meta-Analysis.
Journal article
Koychev I. et al, (2020), J Alzheimers Dis
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Prediction of Alzheimer's disease biomarker status defined by the 'ATN framework' among cognitively healthy individuals: results from the EPAD longitudinal cohort study.
Journal article
Calvin CM. et al, (2020), Alzheimers Res Ther, 12
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Real-world effectiveness, its predictors and onset of action of cholinesterase inhibitors and memantine in dementia: retrospective health record study.
Journal article
Vaci N. et al, (2020), Br J Psychiatry, 1 - 7
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Correlation of Alzheimer’s Disease Neuropathologic Staging with Amyloid and Tau Scintigraphic Imaging Biomarkers
Journal article
KOYCHEV I. et al, (2020), The Journal of Nuclear Medicine