Research projects
European Commission
Healthy Minds from 0-100 years: Optimising the use of European brain imaging cohorts ("Lifebrain"); 2017-2021; Co-applicant with Kristine B. Walhovd, University of Oslo [N, S, GB, D, E, DK, CH]
Medical Research Council (UK):
(1) Predicting MRI abnormalities with longitudinal data of the Whitehall II Substudy; 2012-17; ClinicalTrials.gov Identifier: NCT03335696; PI - co-applicants: Geddes, Kivimäki, Mackay, Singh-Manoux, Smith.
(2) Adult Determinants of Late Life Depression, Cognitive Decline and Physical Functioning - The Whitehall II Ageing Study; 2013-18; Co-applicant with Kivimäki et al., UCL
The HDH Wills 1965 Charitable Trust:
Research into Ageing and Dementia 2012-2022; PI
Klaus Ebmeier
MD FRCPsych
Foundation Chair of Old Age Psychiatry
Supporting epidemiological imaging
Public Engagement
27,500 took part in EU Horizon 2020 brain health survey
An IEHC and Oxford research paper is ranked the 20th most-discussed paper in the world (2017)
The Whitehall II (also known as the Stress and Health Study) website provides public information about the general WHII Study
Seminars in Old Age Psychiatry
Wie sich Pflegebedarf alter und sehr alter Menschen bis 2035 verändert
Further Information:
Research Funding:
European Union:
Diagnostic Molecular Imaging (FP6)
Team Website:
Key publications
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Risk factors associated with loneliness, social isolation, and neuroticism in the UK Biobank cohort
Journal article
de Lange A-MG. et al, (2020), PsyArXiv
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Association of trajectories of depressive symptoms with vascular risk, cognitive function and adverse brain outcomes: The Whitehall II MRI sub-study
Journal article
DEMNITZ N. et al, (2020), Jounal of Psychiatric Research
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Multimodal brain-age prediction and cardiovascular risk: The Whitehall II MRI sub-study.
Journal article
Lange A-MD. et al, (2020), Neuroimage
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Associations Between Longitudinal Trajectories of Cognitive and Social Activities and Brain Health in Old Age.
Journal article
Anatürk M. et al, (2020), JAMA Netw Open, 3
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The maternal brain: Region-specific patterns of brain aging are traceable decades after childbirth.
Journal article
de Lange A-MG. et al, (2020), Hum Brain Mapp
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Subjective Cognitive Complaints Given in Questionnaire: Relationship With Brain Structure, Cognitive Performance and Self-Reported Depressive Symptoms in a 25-Year Retrospective Cohort Study.
Journal article
Topiwala A. et al, (2020), Am J Geriatr Psychiatry
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Integrating large-scale neuroimaging research datasets: harmonisation of white matter hyperintensity measurements across Whitehall and UK Biobank datasets
Journal article
Bordin V. et al, (2020), bioRxiv
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White matter hyperintensities classified according to intensity and spatial location reveal specific associations with cognitive performance
Journal article
Melazzini L. et al, (2020), medRxiv
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Prediction of brain age and cognitive age: quantifying brain and cognitive maintenance in aging
Journal article
ANATURK M. et al, (2020), PsyArXiv