Philip Cowen

• Vulnerability to depression is associated with a failure to acquire implicit social appraisals.

  Bayliss AP. et al, (2017), Cogn Emot, 31, 825 - 833

• Antiepileptic drugs prescribed in pregnancy and prevalence of major congenital malformations: comparative prevalence studies.

  Petersen I. et al, (2017), Clin Epidemiol, 9, 95 - 103

• Fronto-limbic effective connectivity as possible predictor of antidepressant response to SSRI administration.

  Vai B. et al, (2016), Eur Neuropsychopharmacol, 26, 2000 - 2010

• Brain glutamate in anorexia nervosa: A magnetic resonance spectroscopy case control study at 7 Tesla

  Godlewska BR. et al, (2016), Psychopharmacology, 1 - 6

• Risks associated with antipsychotic treatment in pregnancy: Comparative cohort studies based on electronic health records.

  Petersen I. et al, (2016), Schizophr Res, 176, 349 - 356

• Effects of typhoid vaccine on inflammation and sleep in healthy participants: a double-blind, placebo-controlled, crossover study.

  Sharpley AL. et al, (2016), Psychopharmacology, 233, 3429 - 3435

• Effects of the potential lithium-mimetic, ebselen, on impulsivity and emotional processing.

  Masaki C. et al, (2016), Psychopharmacology, 233, 2655 - 2661

• Altered states: psilocybin for treatment-resistant depression.

  Cowen P., (2016), Lancet Psychiatry, 3, 592 - 593

• Cognitive mechanisms of diazepam administration: a healthy volunteer model of emotional processing.

  Pringle A. et al, (2016), Psychopharmacology (Berl), 233, 2221 - 2228

• Frontal Cortex Stimulation Reduces Vigilance to Threat: Implications for the Treatment of Depression and Anxiety.

  Ironside M. et al, (2016), Biological psychiatry, 79, 823 - 830

• Risks and benefits of psychotropic medication in pregnancy: cohort studies based on UK electronic primary care health records.

  Petersen I. et al, (2016), Health Technol Assess, 20, 1 - 176

• Presynaptic Serotoninergic Regulation of Emotional Processing: A Multimodal Brain Imaging Study.

  Selvaraj S. et al, (2015), Biol Psychiatry, 78, 563 - 571

• β-Adrenoceptor blockade modulates fusiform gyrus activity to black versus white faces.

  Terbeck S. et al, (2015), Psychopharmacology (Berl), 232, 2951 - 2958

• Acute fluoxetine modulates emotional processing in young adult volunteers.

  Capitão LP. et al, (2015), Psychol Med, 45, 2295 - 2308

• What has serotonin to do with depression?

  Cowen PJ. and Browning M., (2015), World Psychiatry, 14, 158 - 160

• Effects of seven-day diazepam administration on resting-state functional connectivity in healthy volunteers: A randomized, double-blind study

  Pflanz CP. et al, (2015), Psychopharmacology, 232, 2139 - 2147

• Tianeptine in an experimental medicine model of antidepressant action.

  Cooper CM. et al, (2015), J Psychopharmacol, 29, 582 - 590

• Prebiotic intake reduces the waking cortisol response and alters emotional bias in healthy volunteers

  Schmidt K. et al, (2015), Psychopharmacology, 232, 1793 - 1801

• Evidence-based guidelines for treating depressive disorders with antidepressants: A revision of the 2008 British Association for Psychopharmacology guidelines.

  Cleare A. et al, (2015), J Psychopharmacol, 29, 459 - 525

• Lithium prescribing during pregnancy: A UK primary care database study

  McCrea RL. et al, (2015), PLoS ONE, 10

• How cannabis causes paranoia: using the intravenous administration of ∆9-tetrahydrocannabinol (THC) to identify key cognitive mechanisms leading to paranoia.

  Freeman D. et al, (2015), Schizophr Bull, 41, 391 - 399

• Early effects of tianeptine on emotional processing in healthy volunteers

  Cooper CM. et al, (2015), EUROPEAN NEUROPSYCHOPHARMACOLOGY, 25, S68 - S69

• Anomalous emotional processing in depression, and its significance for treatment

  Harmer C. et al, (2015), EUROPEAN NEUROPSYCHOPHARMACOLOGY, 25, S57 - S58

• Neurochemistry of major depression: a study using magnetic resonance spectroscopy.

  Godlewska BR. et al, (2015), Psychopharmacology (Berl), 232, 501 - 507

• Decision making in young people at familial risk of depression.

  Mannie ZN. et al, (2015), Psychol Med, 45, 375 - 380

• Short-term escitalopram treatment and hippocampal volume.

  Godlewska BR. et al, (2014), Psychopharmacology (Berl), 231, 4579 - 4581

• Opposing neural effects of naltrexone on food reward and aversion: implications for the treatment of obesity.

  Murray E. et al, (2014), Psychopharmacology (Berl), 231, 4323 - 4335

• Short-term escitalopram treatment and hippocampal volume

  Godlewska BR. et al, (2014), Psychopharmacology, 231, 4579 - 4581

• Structural and functional imaging of the hippocampus in young people at familial risk of depression.

  Mannie ZN. et al, (2014), Psychol Med, 44, 2939 - 2948

• Prebiotic intake reduces the waking cortisol response and alters emotional bias in healthy volunteers

  Schmidt K. et al, (2014), EUROPEAN NEUROPSYCHOPHARMACOLOGY, 24, S191 - S191

• Genome-wide association study of antidepressant-induced sexual dysfunction in depressed males

  Crawford A. et al, (2014), EUROPEAN NEUROPSYCHOPHARMACOLOGY, 24, S373 - S374

• Effects of short-term diazepam administration on resting-state functional connectivity in healthy adults

  Pflanz CP. et al, (2014), EUROPEAN NEUROPSYCHOPHARMACOLOGY, 24, S311 - S311

• Discontinuation of antipsychotic medication in pregnancy: a cohort study.

  Petersen I. et al, (2014), Schizophr Res, 159, 218 - 225

• Discontinuation of antipsychotic medication in pregnancy: A cohort study

  Petersen I. et al, (2014), SCHIZOPHRENIA RESEARCH, 159, 218 - 225

• Allowing for non-adherence to treatment in a randomized controlled trial of two antidepressants (citalopram versus reboxetine): an example from the GENPOD trial.

  Wiles NJ. et al, (2014), Psychol Med, 44, 2855 - 2866

• Preliminary evidence that sub-chronic citalopram triggers the re-evaluation of value in intimate partnerships.

  Bilderbeck AC. et al, (2014), Soc Cogn Affect Neurosci, 9, 1419 - 1425

• Adverse effects from antidepressant treatment: randomised controlled trial of 601 depressed individuals.

  Crawford AA. et al, (2014), Psychopharmacology (Berl), 231, 2921 - 2931

• Serotonin and social norms: tryptophan depletion impairs social comparison and leads to resource depletion in a multiplayer harvesting game.

  Bilderbeck AC. et al, (2014), Psychol Sci, 25, 1303 - 1313

• Using neuroimaging to identify neural markers of familial vulnerability to depression

  Cowen P., (2014), INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY, 17, 10 - 10

• Tyrosine-free amino acid mixtures reduce physiologically-evoked release of dopamine in a selective and activity-dependent manner.

  Le Masurier M. et al, (2014), J Psychopharmacol, 28, 561 - 569

• Ketamine infusions for treatment resistant depression: a series of 28 patients treated weekly or twice weekly in an ECT clinic.

  Diamond PR. et al, (2014), J Psychopharmacol, 28, 536 - 544

• Ebselen as a novel IMPase inhibitor as a lithium mimetic

  Churchill G. et al, (2014), INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY, 17, 5 - 6

• Early changes in neural responses to emotional information predict clinical response to antidepressant treatment in depression

  Godlewska B. et al, (2014), INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY, 17, 82 - 82

• Behavioural characterisation of ebselen; a potential lithium-mimetic

  Singh N. et al, (2014), INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY, 17, 132 - 133

• When less is more: a functional magnetic resonance imaging study of verbal working memory in remitted depressed patients.

  Norbury R. et al, (2014), Psychol Med, 44, 1197 - 1203

• I want to help you, but I am not sure why: gaze-cuing induces altruistic giving.

  Rogers RD. et al, (2014), J Exp Psychol Gen, 143, 763 - 777

• Prebiotic intake reduces the waking cortisol response and alters emotional bias in healthy volunteers

  Schmidt K. et al, (2014), EUROPEAN NEUROPSYCHOPHARMACOLOGY, 24, S74 - S74

• Effect of interferon-α on cortical glutamate in patients with hepatitis C: a proton magnetic resonance spectroscopy study.

  Taylor MJ. et al, (2014), Psychol Med, 44, 789 - 795

• Folic acid supplementation for prevention of mood disorders in young people at familial risk: a randomised, double blind, placebo controlled trial.

  Sharpley AL. et al, (2014), J Affect Disord, 167, 306 - 311

• Effects of short-term varenicline administration on cortisol in healthy, non-smoking adults: a randomized, double-blind, study.

  Mocking RJ. et al, (2014), Psychopharmacology (Berl), 231, 143 - 148

• Cortical glutathione levels in young people with bipolar disorder: A pilot study using magnetic resonance spectroscopy

  Godlewska BR. et al, (2014), Psychopharmacology, 231, 327 - 332

• Cortical glutathione levels in young people with bipolar disorder: a pilot study using magnetic resonance spectroscopy.

  Godlewska BR. et al, (2014), Psychopharmacology (Berl), 231, 327 - 332

• Corrigendum to Beta adrenergic blockade reduces utilitarian judgment [Biol. Psychol. 92 (2) (2013) 323-328]

  Sylvia T. et al, (2014), Biological Psychology, 97

• Corrigendum to 'Beta adrenergic blockade reduces utilitarian judgement' [Biol. Psychol., 92, (2013), 323-328] doi:10.1016/j.biopsycho.2012.09.005

  Terbeck S. et al, (2014), Biological Psychology, 103

• Corrigendum to "Beta adrenergic blockade reduces utilitarian judgment" [Biol. Psychol. 92 (2) (2013) 323-328] (DOI:10.1016/j.biopsycho.2012.09.005)

  Sylvia T. et al, (2014), Biological Psychology

• Adverse effects from antidepressant treatment: Randomised controlled trial of 601 depressed individuals

  Crawford AA. et al, (2014), Psychopharmacology, 231, 2921 - 2931

• Early markers of cognitive enhancement: developing an implicit measure of cognitive performance.

  Pringle A. et al, (2013), Psychopharmacology (Berl), 230, 631 - 638

• Early Changes in Neural Responses to Emotional Information Predict Clinical Response to SSRI Treatment in Depression

  Godlewska B. et al, (2013), NEUROPSYCHOPHARMACOLOGY, 38, S446 - S446

• Psychobiotics highlight the pathways to happiness.

  Burnet PW. and Cowen PJ., (2013), Biol Psychiatry, 74, 708 - 709

• Unedited in vivo detection and quantification of γ-aminobutyric acid in the occipital cortex using short-TE MRS at 3T

  Near J. et al, (2013), NMR in Biomedicine, 26, 1353 - 1362

• Unedited in vivo detection and quantification of γ-aminobutyric acid in the occipital cortex using short-TE MRS at 3 T.

  Near J. et al, (2013), NMR Biomed, 26, 1353 - 1362

• 'It's the way that you look at it'--a cognitive neuropsychological account of SSRI action in depression.

  Harmer CJ. and Cowen PJ., (2013), Philosophical transactions of the Royal Society of London. Series B, Biological sciences, 368

• Serotonin, depression and antidepressant action

  Cowen P., (2013), SOUTH AFRICAN JOURNAL OF PSYCHIATRY, 19, 94 - 94

• Behavioral Neurobiology of Depression and Its Treatment

  Cowen PJ. et al, (2013), Current Topics in Behavioral Neurosciences, 14

• The role of serotonin in cognitive function: evidence from recent studies and implications for understanding depression.

  Cowen P. and Sherwood AC., (2013), J Psychopharmacol, 27, 575 - 583

• Effects of pramipexole on the processing of rewarding and aversive taste stimuli

  McCabe C. et al, (2013), Psychopharmacology, 228, 283 - 290

• Cardiovascular and metabolic risk profile in young people at familial risk of depression.

  Mannie ZN. et al, (2013), Br J Psychiatry, 203, 18 - 23

• The effect of the serotonin transporter polymorphism (5-HTTLPR) on amygdala function: A meta-Analysis

  Murphy SE. et al, (2013), Molecular Psychiatry, 18, 512 - 520

• The effect of the serotonin transporter polymorphism (5-HTTLPR) on amygdala function: A meta-Analysis

  Murphy SE. et al, (2013), Molecular Psychiatry, 18, 512 - 520

• The effect of the serotonin transporter polymorphism (5-HTTLPR) on amygdala function: a meta-analysis.

  Murphy SE. et al, (2013), Mol Psychiatry, 18, 512 - 520

• Effects of short-term varenicline administration on emotional and cognitive processing in healthy, non-smoking adults: a randomized, double-blind, study.

  Mocking RJ. et al, (2013), Neuropsychopharmacology, 38, 476 - 484

• Beta adrenergic blockade reduces utilitarian judgement.

  Terbeck S. et al, (2013), Biol Psychol, 92, 323 - 328

• Classification of depressive disorders.

  Cowen PJ., (2013), Curr Top Behav Neurosci, 14, 3 - 13

• 'It's the way that you look at it'--a cognitive neuropsychological account of SSRI action in depression.

  Harmer CJ. and Cowen PJ., (2013), Philos Trans R Soc Lond B Biol Sci, 368

• Short-term SSRI treatment normalises amygdala hyperactivity in depressed patients.

  Godlewska BR. et al, (2012), Psychol Med, 42, 2609 - 2617

• Measuring endogenous changes in serotonergic neurotransmission in humans: a [11C]CUMI-101 PET challenge study.

  Selvaraj S. et al, (2012), Mol Psychiatry, 17, 1254 - 1260

• Measuring endogenous changes in serotonergic neurotransmission in humans: A [¹¹C] CUMI-101 PET challenge study

  Selvaraj S. et al, (2012), Molecular Psychiatry, 17, 1254 - 1260

• Using an experimental medicine model to understand the antidepressant potential of the N-Methyl-D-aspartic acid (NMDA) receptor antagonist memantine.

  Pringle A. et al, (2012), J Psychopharmacol, 26, 1417 - 1423

• Early increase in marker of neuronal integrity with antidepressant treatment of major depression: 1H-magnetic resonance spectroscopy of N-acetyl-aspartate.

  Taylor MJ. et al, (2012), Int J Neuropsychopharmacol, 15, 1541 - 1546

• Current antidepressant treatments: what do we have and what do we need?

  Cowen PJ., (2012), INTERNATIONAL JOURNAL OF PSYCHIATRY IN CLINICAL PRACTICE, 16, 10 - 11

• Using attentional bias modification as a cognitive vaccine against depression.

  Browning M. et al, (2012), Biol Psychiatry, 72, 572 - 579

• Neural processing of reward and punishment in young people at increased familial risk of depression.

  McCabe C. et al, (2012), Biol Psychiatry, 72, 588 - 594

• Neural processing of reward and punishment in young people at increased familial risk of depression

  McCabe C. et al, (2012), Biological Psychiatry, 72, 588 - 594

• Effect of interferon-alfa on cortical glutamate in patients with hepatitis C: a proton magnetic resonance spectroscopy study

  Godlewska BR. et al, (2012), EUROPEAN NEUROPSYCHOPHARMACOLOGY, 22, S198 - S199

• Early increase in the neuronal marker N-acetyl-aspartate with antidepressant treatment of major depression

  Taylor MJ. et al, (2012), EUROPEAN NEUROPSYCHOPHARMACOLOGY, 22, S265 - S265

• Brain serotonin neurotransmission and affect regulation in humans: a positron emission tomography study

  Selvaraj S. et al, (2012), EUROPEAN NEUROPSYCHOPHARMACOLOGY, 22, S193 - S194

• Antidepressants and reward

  McCabe C. et al, (2012), EUROPEAN NEUROPSYCHOPHARMACOLOGY, 22, S140 - S140

• Reply to Burchett, T.S. and Glenn, L.L. 'Measurement validity of tests for implicit negative bias'.

  Terbeck S. et al, (2012), Psychopharmacology (Berl), 222, 723 - 724

• Propranolol reduces implicit negative racial bias.

  Terbeck S. et al, (2012), Psychopharmacology (Berl), 222, 419 - 424

• Negative ion treatment increases positive emotional processing in seasonal affective disorder.

  Harmer CJ. et al, (2012), Psychol Med, 42, 1605 - 1612

• Experimental medicine model shows no depressogenic effects of varenicline

  Pringle A. et al, (2012), INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY, 15, 153 - 153

• Lack of effect of ketamine on cortical glutamate and glutamine in healthy volunteers: a proton magnetic resonance spectroscopy study.

  Taylor MJ. et al, (2012), J Psychopharmacol, 26, 733 - 737

• Lack of effect of ketamine on cortical glutamate and glutamine in healthy volunteers: a proton magnetic resonance spectroscopy study

  Taylor MJ. et al, (2012), JOURNAL OF PSYCHOPHARMACOLOGY, 26, 733 - 737

• In response to "The effect of agomelatine on 5HT(2C) receptors in humans: a clinically relevant mechanism?" by Trevor Norman.

  Sharpley AL. and Cowen PJ., (2012), Psychopharmacology (Berl), 221

• Does baseline fatigue influence treatment response to reboxetine or citalopram in depression? An open label randomized controlled trial.

  Bould H. et al, (2012), J Psychopharmacol, 26, 663 - 669

• Detection of in vivo Brain Serotonin Release in Humans: A 11C-CUMI PET Study

  Selvaraj S. et al, (2012), BIOLOGICAL PSYCHIATRY, 71, 199S - 199S

• Severity of depression and response to antidepressants: GENPOD randomised controlled trial.

  Wiles NJ. et al, (2012), Br J Psychiatry, 200, 130 - 136

• Using an experimental medicine model to understand the antidepressant potential of the N-Methyl-D-aspartic acid (NMDA) receptor antagonist memantine

  Pringle A. et al, (2012), JOURNAL OF PSYCHOPHARMACOLOGY, 26, 1417 - 1423

• Propranolol Reduces Implicit Negative Racial Bias

  Terbeck S. et al, (2012), Psychopharmacology

• Lack of effect of ketamine on cortical glutamate and glutamine in healthy volunteers: a proton magnetic resonance spectroscopy study

  Taylor MJ. et al, (2012), JOURNAL OF PSYCHOPHARMACOLOGY, 26, 733 - 737

• HOW DO ANTIDEPRESSANTS WORK? A POSITRON EMISSION TOMOGRAPHY (PET) STUDY OF BRAIN SEROTONIN LEVELS AND AFFECT REGULATION

  Selvaraj S. et al, (2012), EUROPEAN PSYCHIATRY, 27

• Effects of 7 days of treatment with the cannabinoid type 1 receptor antagonist, rimonabant, on emotional processing.

  Horder J. et al, (2012), J Psychopharmacol, 26, 125 - 132

• Effects of 7 days of treatment with the cannabinoid type 1 receptor antagonist, rimonabant, on emotional processing

  Horder J. et al, (2012), JOURNAL OF PSYCHOPHARMACOLOGY, 26, 125 - 132

• Does baseline fatigue influence treatment response to reboxetine or citalopram in depression? An open label randomized controlled trial

  Bould H. et al, (2012), JOURNAL OF PSYCHOPHARMACOLOGY, 26, 663 - 669

• Efficient γ-aminobutyric acid editing at 3T without macromolecule contamination: MEGA-SPECIAL.

  Near J. et al, (2011), NMR Biomed, 24, 1277 - 1285

• Neural response to angry and disgusted facial expressions in bulimia nervosa.

  Ashworth F. et al, (2011), Psychol Med, 41, 2375 - 2384

• Imaging vulnerability for depression.

  Norbury R. et al, (2011), Mol Psychiatry, 16, 1067 - 1068

• The D2 antagonist sulpiride modulates the neural processing of both rewarding and aversive stimuli in healthy volunteers

  McCabe C. et al, (2011), Psychopharmacology, 217, 271 - 278

• Efficacy markers in depression.

  Harmer CJ. et al, (2011), J Psychopharmacol, 25, 1148 - 1158

• Efficacy markers in depression

  Harmer CJ. et al, (2011), Journal of Psychopharmacology, 25, 1148 - 1158

• Agomelatine facilitates positive versus negative affective processing in healthy volunteer models.

  Harmer CJ. et al, (2011), J Psychopharmacol, 25, 1159 - 1167

• Agomelatine facilitates positive versus negative affective processing in healthy volunteer models

  Harmer CJ. et al, (2011), Journal of Psychopharmacology, 25, 1159 - 1167

• A cognitive neuropsychological model of antidepressant drug action.

  Pringle A. et al, (2011), Prog Neuropsychopharmacol Biol Psychiatry, 35, 1586 - 1592

• SSRI administration reduces resting state functional connectivity in dorso-medial prefrontal cortex

  McCabe C. et al, (2011), Molecular Psychiatry, 16, 592 - 594

• SSRI administration reduces resting state functional connectivity in dorso-medial prefrontal cortex.

  McCabe C. et al, (2011), Mol Psychiatry, 16, 592 - 594

• Polymorphism of the 5-HT transporter and response to antidepressants: randomised controlled trial.

  Lewis G. et al, (2011), Br J Psychiatry, 198, 464 - 471

• Short-term NK1 receptor antagonism and emotional processing in healthy volunteers.

  Pringle A. et al, (2011), Psychopharmacology (Berl), 215, 239 - 246

• Has psychopharmacology got a future?

  Cowen PJ., (2011), Br J Psychiatry, 198, 333 - 335

• Decreased regional gray matter volume in S allele carriers of the 5-HTTLPR triallelic polymorphism

  Selvaraj S. et al, (2011), Molecular Psychiatry, 16, 472 - 473

• Frontolimbic responses to emotional faces in young people at familial risk of depression.

  Mannie ZN. et al, (2011), J Affect Disord, 130, 127 - 132

• Elevated cortical glutamate in young people at increased familial risk of depression.

  Taylor MJ. et al, (2011), Int J Neuropsychopharmacol, 14, 255 - 259

• Decreased neural response to fear after a short-term SSRI treatment: a 3T functional magnetic resonance imaging study

  Godlewska B. et al, (2011), EUROPEAN NEUROPSYCHOPHARMACOLOGY, 21, S73 - S73

• Serotonin revisited.

  Cowen PJ. and Lucki I., (2011), Psychopharmacology (Berl), 213, 167 - 169

• Does agomelatine block 5-HT2C receptors in humans?

  Sharpley AL. et al, (2011), Psychopharmacology (Berl), 213, 653 - 655

• Diminished brain 5-HT transporter binding in major depression: a positron emission tomography study with [11C]DASB.

  Selvaraj S. et al, (2011), Psychopharmacology (Berl), 213, 555 - 562

• 5-HT and depression: is the glass half-full?

  Sharp T. and Cowen PJ., (2011), Curr Opin Pharmacol, 11, 45 - 51

• The D2 antagonist sulpiride modulates the neural processing of both rewarding and aversive stimuli in healthy volunteers

  McCabe C. et al, (2011), Psychopharmacology, 217, 271 - 278

• Serotonin and dopamine play complementary roles in gambling to recover losses.

  Campbell-Meiklejohn D. et al, (2011), Neuropsychopharmacology, 36, 402 - 410

• Serotonergic activity influences the cognitive appraisal of close intimate relationships in healthy adults

  Bilderbeck AC. et al, (2011), Biological psychiatry, 69, 720 - 725

• A single dose of mirtazapine modulates neural responses to emotional faces in healthy people.

  Rawlings NB. et al, (2010), Psychopharmacology (Berl), 212, 625 - 634

• Serotonin transporter polymorphisms (SLC6A4 insertion/deletion and rs25531) do not affect the availability of 5-HTT to [11C] DASB binding in the living human brain.

  Murthy NV. et al, (2010), Neuroimage, 52, 50 - 54

• Lack of effect of citalopram on magnetic resonance spectroscopy measures of glutamate and glutamine in frontal cortex of healthy volunteers.

  Taylor MJ. et al, (2010), J Psychopharmacol, 24, 1217 - 1221

• Erythropoietin modulates neural and cognitive processing of emotional information in biomarker models of antidepressant drug action in depressed patients.

  Miskowiak KW. et al, (2010), Psychopharmacology (Berl), 210, 419 - 428

• 5-HT(1A) receptor binding in euthymic bipolar patients using positron emission tomography with [carbonyl-(11)C]WAY-100635.

  Sargent PA. et al, (2010), J Affect Disord, 123, 77 - 80

• Simplified quantification of 5-HT2A receptors in the human brain with [11C]MDL 100,907 PET and non-invasive kinetic analyses.

  Meyer PT. et al, (2010), Neuroimage, 50, 984 - 993

• Pindolol augmentation of serotonin reuptake inhibitors for the treatment of depressive disorder: a systematic review.

  Whale R. et al, (2010), J Psychopharmacol, 24, 513 - 520

• NK1 receptor antagonism and emotional processing in healthy volunteers.

  Chandra P. et al, (2010), J Psychopharmacol, 24, 481 - 487

• Increased neural response to fear in patients recovered from depression: a 3T functional magnetic resonance imaging study.

  Norbury R. et al, (2010), Psychol Med, 40, 425 - 432

• A functional magnetic resonance imaging study of verbal working memory in young people at increased familial risk of depression.

  Mannie ZN. et al, (2010), Biol Psychiatry, 67, 471 - 477

• Short-term NK1 receptor antagonism and emotional processing in healthy volunteers

  Pringle A. et al, (2010), Psychopharmacology, 1 - 8

• Reduced neural response to reward following 7 days treatment with the cannabinoid CB1 antagonist rimonabant in healthy volunteers

  Horder J. et al, (2010), The international journal of neuropsychopharmacology / official scientific journal of the Collegium Internationale Neuropsychopharmacologicum, 13, 1103 - 1113

• Not fade away: the HPA axis and depression.

  Cowen PJ., (2010), Psychol Med, 40, 1 - 4

• Diminished neural processing of aversive and rewarding stimuli during selective serotonin reuptake inhibitor treatment

  McCabe C. et al, (2010), Biological psychiatry, 67, 439 - 445

• Normal glutamate but elevated myo-inositol in anterior cingulate cortex in recovered depressed patients.

  Taylor MJ. et al, (2009), J Affect Disord, 119, 186 - 189

• High-density negative ion treatment increases positive affective memory.

  Malcolm CP. et al, (2009), Psychol Med, 39, 1930 - 1932

• Effects of erythropoietin on emotional processing biases in patients with major depression: an exploratory fMRI study.

  Miskowiak KW. et al, (2009), Psychopharmacology (Berl), 207, 133 - 142

• Short-term antidepressant treatment modulates amygdala response to happy faces.

  Norbury R. et al, (2009), Psychopharmacology (Berl), 206, 197 - 204

• Effect of acute antidepressant administration on negative affective bias in depressed patients.

  Harmer CJ. et al, (2009), Am J Psychiatry, 166, 1178 - 1184

• A big tent?

  Cowen PJ., (2009), Psychiatric Bulletin, 33

• The role of serotonin in nonnormative risky choice: the effects of tryptophan supplements on the "reflection effect" in healthy adult volunteers.

  Murphy SE. et al, (2009), J Cogn Neurosci, 21, 1709 - 1719

• Why do antidepressants take so long to work? A cognitive neuropsychological model of antidepressant drug action.

  Harmer CJ. et al, (2009), Br J Psychiatry, 195, 102 - 108

• Commentary on STAR*D: a summary and UK perspective.

  Cowen PJ., (2009), J Psychopharmacol, 23, 618 - 619

• Acute administration of the cannabinoid CB1 antagonist rimonabant impairs positive affective memory in healthy volunteers.

  Horder J. et al, (2009), Psychopharmacology (Berl), 205, 85 - 91

• Negative self-beliefs in relation to eating disorder and depressive symptoms: Different themes are characteristic of the two sets of symptoms in those with eating disorders and/or depression

  Cooper MJ. and Cowen P., (2009), Journal of Cognitive Psychotherapy, 23, 147 - 159

• Effect of a single dose of citalopram on amygdala response to emotional faces.

  Murphy SE. et al, (2009), Br J Psychiatry, 194, 535 - 540

• Oxytocin enhances processing of positive versus negative emotional information in healthy male volunteers.

  Di Simplicio M. et al, (2009), J Psychopharmacol, 23, 241 - 248

• Memory impairment in young women at increased risk of depression: influence of cortisol and 5-HTT genotype.

  Mannie ZN. et al, (2009), Psychol Med, 39, 757 - 762

• Early effects of mirtazapine on emotional processing.

  Arnone D. et al, (2009), Psychopharmacology (Berl), 203, 685 - 691

• Brain serotonin transporter binding in former users of MDMA ('ecstasy').

  Selvaraj S. et al, (2009), Br J Psychiatry, 194, 355 - 359

• Short-term serotonergic but not noradrenergic antidepressant administration reduces attentional vigilance to threat in healthy volunteers.

  Murphy SE. et al, (2009), Int J Neuropsychopharmacol, 12, 169 - 179

• NK1 receptor antagonism and the neural processing of emotional information in healthy volunteers

  McCabe C. et al, (2009), The international journal of neuropsychopharmacology / official scientific journal of the Collegium Internationale Neuropsychopharmacologicum, 12, 1261 - 1274

• NK1 receptor antagonism and the neural processing of emotional information in healthy volunteers

  McCabe C. et al, (2009), International Journal of Neuropsychopharmacology, 1 - 14

• Neural representation of reward in recovered depressed patients

  McCabe C. et al, (2009), Psychopharmacology, 205, 667 - 677

• Wake-up call for British psychiatry Reply

  Craddock N. et al, (2008), BRITISH JOURNAL OF PSYCHIATRY, 193, 517 - 517

• Emotional face processing in women with high and low levels of eating disorder related symptoms.

  Jones L. et al, (2008), Eat Behav, 9, 389 - 397

• Authors' reply

  Craddock N. et al, (2008), British Journal of Psychiatry, 193

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• A 5-HT2C receptor promoter polymorphism (HTR2C - 759C/T) is associated with obesity in women, and with resistance to weight loss in heterozygotes.

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• Acute administration of citalopram facilitates memory consolidation in healthy volunteers.

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• Tyrosine depletion attenuates the behavioural stimulant effects of amphetamine and cocaine in rats.

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• The effect of Li 1370, extract of Ginkgo biloba, on REM sleep in humans.

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• Researching the antidepressant actions of Hypericum perforatum (St. John's wort) in animals and man.

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• A database of [11C]WAY-100635 binding ins healthy volunteers: relationship to demographic, physiological and personality variables

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• Low-dose citalopram as a 5-HT neuroendocrine probe.

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• Decreased tryptophan availability but normal post-synaptic 5-HT2c receptor sensitivity in chronic fatigue syndrome.

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• Decreased sensitivity of 5-HT(1D) receptors in melancholic depression.

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• Administration of the beta-adrenoceptor blocker propranolol impairs the processing of facial expressions of sadness.

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• Repetitive transcranial magnetic stimulation to right prefrontal cortex does not modulate the psychostimulant effects of amphetamine.

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• 5-HT1A receptor binding in panic disorder; comparison with depressive disorder and healthy volunteers using PET and [11C]WAY-100635

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• beta-blocker binding to human 5-HT(1A) receptors in vivo and in vitro: implications for antidepressant therapy.

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• Psychopharmacology of 5-HT(1A) receptors.

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• Drug action at the 5-HT(1A) receptor in vivo: autoreceptor and postsynaptic receptor occupancy examined with PET and [carbonyl-(11)C]WAY-100635.

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• Serotonin transporter (5-HTT) promoter genotype may influence the prolactin response to clomipramine.

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• Olanzapine increases slow-wave sleep: evidence for blockade of central 5-HT(2C) receptors in vivo.

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• Modelling a loss event: effect of imagined bereavement on the hypothalamic-pituitary-adrenal axis.

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• Impaired regulation of brain serotonin function during dieting in women recovered from depression.

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• Acute effects of LI 160 (extract of Hypericum perforatum, St John's wort) and two of its constituents on neuroendocrine responses in the rat.

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• Comparison of the effects of alpha-methyl-p-tyrosine and a tyrosine-free amino acid load on extracellular noradrenaline in the rat hippocampus in vivo.

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• Slow, repetitive transcranial magnetic stimulation was effective for major depression

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• Neuroendocrine evidence for dopaminergic actions of hypericum extract (LI 160) in healthy volunteers.

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• The effects of chronic administration of hydrocortisone on cognitive function in normal male volunteers.

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• Covariation of activity in habenula and dorsal raphé nuclei following tryptophan depletion.

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• Effect of a tyrosine-free amino acid mixture on regional brain catecholamine synthesis and release.

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• Effect of a long-term low tryptophan diet on the prolactin responses to the 5-HT1A and 5-HT2C agonists, 8-OH-DPAT and mCPP in the male rat.

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• Attenuation of some subjective effects of amphetamine following tyrosine depletion.

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• Probing the function of 5-HT<inf>1B/1D</inf> receptors in psychiatric patients

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• Clomipramine enhances the cortisol response to 5-HTP: implications for the therapeutic role of 5-HT2 receptors.

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• Antidepressant-like effect of Hypericum perforatum (St John's wort) on the sleep polysomnogram.

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• Electrophysiological and neurochemical evidence that pindolol has agonist properties at the 5-HT1A autoreceptor in vivo.

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• BETA-ADRENOCEPTOR FUNCTION IN THE PINEAL-GLAND DURING DESIPRAMINE TREATMENT

  COWEN P., (1987), INTERNATIONAL JOURNAL OF NEUROSCIENCE, 32, 568 - 569

• Binding of yohimbine and imipramine to platelets in depressive illness.

  Braddock L. et al, (1986), Psychol Med, 16, 765 - 773

• Changes in mood, appetite and psychomotor retardation in depressed patients given ECT.

  Browning SM. and Cowen PJ., (1986), Br J Psychiatry, 149, 371 - 373

• The effect of diazepam on indices of 5-HT function in man.

  Nutt DJ. et al, (1986), Pharmacol Biochem Behav, 24, 1491 - 1495

• The effect of lithium on 5-HT-mediated neuroendocrine responses and platelet 5-HT receptors.

  Glue PW. et al, (1986), Psychopharmacology (Berl), 90, 398 - 402

• Neuroendocrine responses as a probe into the mechanisms of action of electroconvulsive therapy.

  Cowen PJ., (1986), Ann N Y Acad Sci, 462, 163 - 171

• Desipramine treatment in normal subjects. Effects on neuroendocrine responses to tryptophan and on platelet serotonin (5-HT)-related receptors.

  Cowen PJ. et al, (1986), Arch Gen Psychiatry, 43, 61 - 67

• Clomipramine enhances prolactin and growth hormone responses to L-tryptophan.

  Anderson IM. and Cowen PJ., (1986), Psychopharmacology (Berl), 89, 131 - 133

• The pharmacokinetics of L-tryptophan following its intravenous and oral administration.

  Green AR. et al, (1985), Br J Clin Pharmacol, 20, 317 - 321

• Plasma melatonin during desmethylimipramine treatment: evidence for changes in noradrenergic transmission.

  Cowen PJ. et al, (1985), Br J Clin Pharmacol, 19, 799 - 805

• Effects of the contraceptive pill on sedative responses to clonidine and apomorphine in normal women.

  Chalmers JS. et al, (1985), Psychol Med, 15, 363 - 367

• Increased platelet membrane [3H]-LSD binding in patients on chronic neuroleptic treatment.

  Schächter M. et al, (1985), Br J Clin Pharmacol, 19, 453 - 457

• Treatment with beta-adrenoceptor blockers reduces plasma melatonin concentration.

  Cowen PJ. et al, (1985), Br J Clin Pharmacol, 19, 258 - 260

• The benzodiazepine antagonist, Ro 15-1788 does not decrease ethanol withdrawal convulsions in rats.

  Little HJ. et al, (1985), Eur J Pharmacol, 107, 375 - 377

• Responses of prolactin and growth hormone to L-tryptophan infusion: effects in normal subjects and schizophrenic patients receiving neuroleptics.

  Cowen PJ. et al, (1985), Psychopharmacology (Berl), 86, 164 - 169

• NORADRENERGIC TRANSMISSION IN THE PINEAL-GLAND DURING DESMETHYLIMIPRAMINE TREATMENT

  COWEN P. et al, (1985), BRITISH JOURNAL OF CLINICAL PHARMACOLOGY, 19, P579 - P580

• CHANGES IN IMIPRAMINE AND ALPHA-2-ADRENOCEPTOR BINDING-SITES IN THE EARLY PUERPERIUM

  BEST N. et al, (1985), BRITISH JOURNAL OF CLINICAL PHARMACOLOGY, 19, P555 - P556

• Changes in the binding to platelets of [3H]imipramine and [3H]yohimbine in normal subjects taking amitriptyline.

  Braddock LE. et al, (1984), Neuropharmacology, 23, 285 - 286

• The effect of amitriptyline treatment on the growth hormone response to apomorphine.

  Cowen PJ. et al, (1984), Psychopharmacology (Berl), 83, 378 - 379

• PLATELET (H-3)-LSD BINDING IN PATIENTS ON CHRONIC PHENOTHIAZINE AND THIOXANTHENE THERAPY

  SCHACHTER M. et al, (1984), BRITISH JOURNAL OF CLINICAL PHARMACOLOGY, 17, P619 - P620

• Effect of beta 2-adrenoceptor agonists on serotonin biochemistry and function.

  Green AR. et al, (1984), Adv Biochem Psychopharmacol, 39, 285 - 288

• Changes in the binding to platelets of [³H]imipramine and [³H]yohimbine in normal subjects taking amitriptyline

  Braddock LE. et al, (1984), Neuropharmacology, 23, 285 - 286

• AMITRIPTYLINE REDUCES THE GROWTH-HORMONE RESPONSE TO APOMORPHINE

  BRADDOCK L. et al, (1984), BRITISH JOURNAL OF CLINICAL PHARMACOLOGY, 17, P642 - P643

• Direct radioimmunoassay and gas chromatography-mass spectrometry compared for determination of melatonin in plasma.

  Fraser S. et al, (1983), Clin Chem, 29, 1703 - 1704

• Studies on the mechanisms by which clenbuterol, a beta-adrenoceptor agonist, enhances 5-HT-mediated behaviour and increases metabolism of 5-HT in the brain of the rat.

  Nimgaonkar VL. et al, (1983), Neuropharmacology, 22, 739 - 749

• Atenolol reduces plasma melatonin concentration in man.

  Cowen PJ. et al, (1983), Br J Clin Pharmacol, 15, 579 - 581

• Changes in platelet alpha 2-adrenoceptor binding post partum: possible relation to maternity blues.

  Metz A. et al, (1983), Lancet, 1, 495 - 498

• Direct radioimmunoassay for melatonin in plasma.

  Fraser S. et al, (1983), Clin Chem, 29, 396 - 397

• The effect of chronic antidepressant administration on beta-adrenoceptor function of the rat pineal.

  Cowen PJ. et al, (1983), Br J Pharmacol, 78, 89 - 96

• Comparison of the effects of chronic desmethylimipramine administration on alpha 2- and beta-adrenoceptors in different regions of rat brain.

  Stanford C. et al, (1983), Neuroscience, 8, 161 - 164

• Further evidence for a relationship between changes in GABA concentration in rat brain and enhanced monoamine-mediated behavioural responses following repeated electroconvulsive shock.

  Green AR. et al, (1982), Neuropharmacology, 21, 981 - 984

• Electroconvulsive therapy and the brain: evidence for increased dopamine-mediated responses.

  Costain DW. et al, (1982), Lancet, 2, 400 - 404

• Abstinence symptoms after withdrawal of tranquillising drugs: is there a common neurochemical mechanism?

  Cowen PJ. and Nutt DJ., (1982), Lancet, 2, 360 - 362

• beta-Adrenoceptor agonists enhance 5-hydroxytryptamine-mediated behavioural responses.

  Cowen PJ. et al, (1982), Br J Pharmacol, 76, 265 - 270

• Unusual interactions of benzodiazepine receptor antagonists.

  Nutt DJ. et al, (1982), Nature, 295, 436 - 438

• Using Ro 15-1788 to investigate the benzodiazepine receptor in vivo: studies on the anticonvulsant and sedative effect of melatonin and the convulsant effect of the benzodiazepine Ro 05-3663.

  Green AR. et al, (1982), Psychopharmacology (Berl), 78, 293 - 295

• Repeated administration of subconvulsant doses of GABA antagonist drugs. I. Effect on seizure threshold (kindling).

  Nutt DJ. et al, (1982), Psychopharmacology (Berl), 76, 84 - 87

• Repeated administration of subconvulsant doses of GABA antagonist drugs. II. Effect on monoamine-mediated behaviour.

  Cowen PJ. et al, (1982), Psychopharmacology (Berl), 76, 88 - 91

• β‐ADRENOCEPTOR AGONISTS ENHANCE 5‐HYDROXYTRYPTAMINE‐MEDIATED BEHAVIOURAL RESPONSES

  COWEN PJ. et al, (1982), British Journal of Pharmacology, 76, 265 - 270

• Antidepressant treatment and β-adrenoceptor function in the rat pineal

  Cowen PJ. and Fraser S., (1981), British Journal of Pharmacology, 74

• Studies on the post-ictal rise in seizure threshold.

  Nutt DJ. et al, (1981), Eur J Pharmacol, 71, 287 - 295

• Ethyl beta-carboline carboxylate lowers seizure threshold and antagonizes flurazepam-induced sedation in rats.

  Cowen PJ. et al, (1981), Nature, 290, 54 - 55

• Drug-induced alterations of the post-ictal seizure threshold increase

  Cowen PJ. et al, (1981), British Journal of Pharmacology, 73

• Repeated electroconvulsive shock does not increase the susceptibility of rats to a cage convulsant (isopropylbicyclophosphate).

  Cowen PJ. et al, (1980), Neuropharmacology, 19, 1025 - 1026

• On the measurement in rats of the convulsant effect of drugs and the changes which follow electroconvulsive shock.

  Nutt DJ. et al, (1980), Neuropharmacology, 19, 1017 - 1023

• Enhanced 5-hydroxytryptamine and dopamine-mediated behavioural responses following convulsions--II. The effects of anaesthesia and current conditions on the appearance of enhanced responses following electroconvulsive shock.

  Cowen PJ. et al, (1980), Neuropharmacology, 19, 901 - 906

• Effect of anaesthetic administration on the appearance of enhanced monoamine-mediated behaviours following electroconvulsive shock

  Cowen PJ. et al, (1980), British Journal of Pharmacology, 70

• Can saliva testing replace blood measurements for health monitoring? Insights from a correlation study of salivary and whole blood glutathione in humans.

  Ngamchuea K. et al, Analyst

• Backing into the future: pharmacological approaches to the management of resistant depression

  Cowen PJ., Psychological Medicine

Key Publications

• Lack of effect of ketamine on cortical glutamate and glutamine in healthy volunteers: a proton magnetic resonance spectroscopy study.

  Taylor MJ. et al, (2012), J Psychopharmacol, 26, 733 - 737
• Early increase in marker of neuronal integrity with antidepressant treatment of major depression: 1H-magnetic resonance spectroscopy of N-acetyl-aspartate.

  Taylor MJ. et al, (2012), Int J Neuropsychopharmacol, 15, 1541 - 1546
• Effects of 7 days of treatment with the cannabinoid type 1 receptor antagonist, rimonabant, on emotional processing.

  Horder J. et al, (2012), J Psychopharmacol, 26, 125 - 132
• In response to "The effect of agomelatine on 5HT(2C) receptors in humans: a clinically relevant mechanism?" by Trevor Norman.

  Sharpley AL. and Cowen PJ., (2012), Psychopharmacology (Berl), 221
• Lack of effect of ketamine on cortical glutamate and glutamine in healthy volunteers: a proton magnetic resonance spectroscopy study

  Taylor MJ. et al, (2012), JOURNAL OF PSYCHOPHARMACOLOGY, 26, 733 - 737

Recent Publications

• Vulnerability to depression is associated with a failure to acquire implicit social appraisals.

  Bayliss AP. et al, (2017), Cogn Emot, 31, 825 - 833
• Antiepileptic drugs prescribed in pregnancy and prevalence of major congenital malformations: comparative prevalence studies.

  Petersen I. et al, (2017), Clin Epidemiol, 9, 95 - 103
• Fronto-limbic effective connectivity as possible predictor of antidepressant response to SSRI administration.

  Vai B. et al, (2016), Eur Neuropsychopharmacol, 26, 2000 - 2010
• Brain glutamate in anorexia nervosa: A magnetic resonance spectroscopy case control study at 7 Tesla

  Godlewska BR. et al, (2016), Psychopharmacology, 1 - 6
• Risks associated with antipsychotic treatment in pregnancy: Comparative cohort studies based on electronic health records.

  Petersen I. et al, (2016), Schizophr Res, 176, 349 - 356