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Thirty acute psychiatric patients were examined prospectively at the beginning of neuroleptic treatment for acute psychotic symptoms and on average 16 days later. Two alternative hypotheses were examined: 1) neuroleptic treatment affects the levels of serum iron and transferrin; 2) acute akathisia developing during the initial few weeks of treatment is associated with low levels of serum iron and transferrin, either initially or at follow up or both. Serum iron levels did not change on repeat measurement, while there was a small, but significant decrease of serum transferrin. There was a significantly greater decrease in iron and transferrin levels in patients with akathisia on follow up compared with non-akathisics. In addition, akathisia ratings were highly correlated with serum transferrin levels on follow up.

More information
Type

Journal article

Journal

J Neurol Neurosurg Psychiatry

Publication Date

04/1991

Volume

54

Pages

363 - 364

Keywords

Adult, Akathisia, Drug-Induced, Antipsychotic Agents, Dyskinesia, Drug-Induced, Female, Follow-Up Studies, Humans, Iron, Male, Neurologic Examination, Parkinson Disease, Secondary, Psychomotor Agitation, Psychotic Disorders, Transferrin