Meta-analysis of magnetic resonance imaging studies of the corpus callosum in bipolar disorder.
Arnone D., McIntosh AM., Chandra P., Ebmeier KP.
The corpus callosum (CC) plays a pivotal role in inter-hemispheric transfer and integration of information and is a relatively understudied structure in bipolar disorder (BD). Magnetic resonance imaging (MRI) studies have reported callosal abnormalities in this condition but findings have been inconsistent. Structural changes affecting the CC may underlie functional abnormalities in BD and could contribute to, or explain the pathophysiology of, the condition.