A systematic review and meta-analysis of clinical predictors of lithium response in bipolar disorder.
Hui TP., Kandola A., Shen L., Lewis G., Osborn DPJ., Geddes JR., Hayes JF.
OBJECTIVE: To determine clinical predictors of lithium response in bipolar disorder. METHODS: Systematic review of studies examining clinical predictors of lithium response was conducted. Meta-analyses were performed when ≥2 studies examined the same potential predictor. RESULTS: A total of 71 studies, including over 12 000 patients, identified six predictors of good response: mania-depression-interval sequence [odds ratio (OR): 4.27; 95% CI: 2.61, 6.97; P