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Sexual dysfunction is a common side effect of most antidepressants. Lower rates are reported with some newer agents such as reboxetine and bupropion. The evidence base for its management is limited but growing, with most approaches only tested in a small number of trials. Available strategies include watchful waiting, the use of short drug holidays, and a change of antidepressant. Many specific antidotes have been trialed but with lack of convincing benefit in most cases. However, where antidepressants cause erectile dysfunction, the use of sildenafil has the largest and most consistent evidence base.

Original publication




Journal article


Curr Psychiatry Rep

Publication Date





431 - 436


Antidepressive Agents, Bupropion, Buspirone, Depressive Disorder, Erectile Dysfunction, Female, Ginkgo biloba, Granisetron, Humans, Male, Randomized Controlled Trials as Topic, Sexual Dysfunction, Physiological