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A recent “umbrella” review examined various biomarkers relating to the serotonin system, and concluded there was no consistent evidence implicating serotonin in the pathophysiology of depression. We present reasons for why this conclusion is overstated, including methodological weaknesses in the review process, selective reporting of data, over-simplification, and errors in the interpretation of neuropsychopharmacological findings. We use the examples of tryptophan depletion and serotonergic molecular imaging, the two research areas most relevant to the investigation of serotonin, to illustrate this.

Original publication

DOI

10.1038/s41380-023-02095-y

Type

Journal article

Journal

Mol Psychiatry

Publication Date

08/2023

Volume

28

Pages

3149 - 3152

Keywords

Serotonin, Depression