Cookies on this website
We use cookies to ensure that we give you the best experience on our website. If you click 'Continue' we'll assume that you are happy to receive all cookies and you won't see this message again. Click 'Find out more' for information on how to change your cookie settings.

Eight patients with generalised anxiety disorder (GAD) and eight matched healthy controls had their polysomnogram measured on two occasions separated by 1 week. On one occasion they received the 5-HT2 receptor antagonist, ritanserin (5 mg orally) and on the other matching placebo. The increase in slow wave sleep produced by ritanserin was the same in GAD patients as in healthy controls. These findings do not support the hypothesis that GAD is associated with a generalised hypersensitivity of brain 5-HT2 receptors; however, the present data cannot exclude the presence of a regionally specific change in this receptor subtype in anxiety disorders.

Type

Journal article

Journal

Psychopharmacology (Berl)

Publication Date

1992

Volume

108

Pages

387 - 389

Keywords

Adult, Anxiety Disorders, Double-Blind Method, Female, Humans, Male, Middle Aged, Psychiatric Status Rating Scales, Receptors, Serotonin, Ritanserin, Sleep Stages