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5-Hydroxytryptamine (5-HT) receptor binding was determined in intact human platelets using 125I-iodolysergic acid diethylamide (125I-iodoLSD). The assay revealed that platelets possess a single population of specific binding sites for 125I-iodoLSD which have a high affinity for the 5-HT2 receptor antagonists, ketanserin and spiperone. There was no difference in platelet 125I-iodoLSD receptor binding between depressed patients and controls. However, treatment with tricyclic antidepressants increased the number of 125I-iodoLSD receptor binding sites without significantly altering their affinity.


Journal article


J Affect Disord

Publication Date





45 - 50


Adult, Antidepressive Agents, Tricyclic, Binding Sites, Blood Platelets, Depressive Disorder, Female, Humans, Iodine Radioisotopes, Male, Middle Aged, Receptors, Serotonin