Cookies on this website
We use cookies to ensure that we give you the best experience on our website. If you click 'Continue' we'll assume that you are happy to receive all cookies and you won't see this message again. Click 'Find out more' for information on how to change your cookie settings.

1. The use of normal volunteers in the study of human central nervous system biochemistry and pharmacology is exemplified by studies on serotonin and noradrenaline function. 2. It is concluded that benzodiazepines reduce and lithium enhances brain serotonin function. 3. The studies on noradrenaline reveal that in normal controls there does not appear to be tonic inhibitory activity at presynaptic alpha-2-adrenoceptors and that antidepressants, even after chronic treatment, still increase noradrenergic synaptic throughput.


Journal article


Pharmaceutical Medicine

Publication Date





127 - 133