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OBJECTIVE: People with 'prodromal' symptoms have a very high risk of developing psychosis. We examined the neurocognitive basis of this vulnerability by using functional MRI to study subjects with an at-risk mental state (ARMS) while they performed a random movement generation task. METHOD: Cross-sectional comparison of individuals with an ARMS (n = 17), patients with first episode schizophreniform psychosis (n = 10) and healthy volunteers (n = 15). Subjects were studied using functional MRI while they performed a random movement generation paradigm. RESULTS: During random movement generation, the ARMS group showed less activation in the left inferior parietal cortex than controls, but greater activation than in the first episode group. CONCLUSION: The ARMS is associated with abnormalities of regional brain function that are qualitatively similar to those in patients who have recently presented with psychosis but less severe.

Original publication




Journal article


Acta Psychiatr Scand

Publication Date





295 - 301


Adult, Antipsychotic Agents, Causality, Cerebral Cortex, Cross-Sectional Studies, Disease Susceptibility, Humans, Magnetic Resonance Imaging, Mental Health, Motor Activity, Psychotic Disorders, Schizophrenia, Task Performance and Analysis