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BACKGROUND: It is not clear how far brain abnormalities in early-onset schizophrenia result from progressive neurodevelopmental or neurodegenerative processes. Aims To investigate the hypothesis that structural brain abnormalities in adolescent-onset schizophrenia are progressive in the early phase of the illness. METHOD: A magnetic resonance imaging case-control study of 16 adolescents with schizophrenia (mean age 16.6 years, s.d.=1.9 years) with a mean time of 2.7 years (s.d.=1.7 years) between measurements and 16 matched controls (average age 16.0 years, s.d.=2.0 years) with a mean time of 1.7 years (s.d.=0.5 years) between measurements. RESULTS: There was no evidence of progressive structural brain changes during late adolescence. Significant ventricular enlargement (greater in males) and left-sided temporal lobe changes were evident from the outset of the illness. CONCLUSIONS: Neurodevelopmental brain abnormalities are non-progressive during late adolescence.

Original publication




Journal article


Br J Psychiatry

Publication Date





339 - 344


Adolescent, Age of Onset, Analysis of Variance, Brain Diseases, Case-Control Studies, Cerebral Ventricles, Child, Child, Preschool, Female, Humans, Magnetic Resonance Imaging, Male, Schizophrenia, Sex Characteristics, Temporal Lobe