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Understanding the mechanisms for communication in the brain remains one of the most challenging scientific questions. The communication through coherence (CTC) hypothesis was originally proposed 10 years ago, stating that two groups of neurons communicate most effectively when their excitability fluctuations are coordinated in time (i.e., coherent), and this control by cortical coherence is a fundamental brain mechanism for large-scale, distant communication. In light of new evidence from whole-brain computational modelling of multimodal neuroimaging data, we link CTC to the concept of metastability, which refers to a rich exploration of the functional repertoire made possible by the underlying structural whole-brain connectivity.

Original publication

DOI

10.1016/j.tins.2016.01.001

Type

Journal article

Journal

Trends Neurosci

Publication Date

03/2016

Volume

39

Pages

125 - 135

Keywords

communication through coherence, metastability, synchronisation, whole-brain-modelling, Animals, Brain, Computer Simulation, Connectome, Humans, Models, Neurological, Neural Pathways