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BACKGROUND: Asthma is a heterogeneous disease in which age of onset plays an important role. OBJECTIVE: We sought to identify the genetic variants associated with time to asthma onset (TAO). METHODS: We conducted a large-scale meta-analysis of 9 genome-wide association studies of TAO (total of 5462 asthmatic patients with a broad range of age of asthma onset and 8424 control subjects of European ancestry) performed by using survival analysis techniques. RESULTS: We detected 5 regions associated with TAO at the genome-wide significant level (P 

Original publication




Journal article


J Allergy Clin Immunol

Publication Date





1071 - 1080


Asthma, CYLD, NOD2, age of onset, conditional analysis, genetics, genome-wide association study, survival analysis, Adolescent, Age of Onset, Asthma, Child, Chromosomes, Human, Pair 16, Deubiquitinating Enzyme CYLD, Female, Genetic Variation, Genome-Wide Association Study, Genotype, Humans, Male, Nod2 Signaling Adaptor Protein, Tumor Suppressor Proteins, White People