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Brief high frequency stimulation induces long-term potentiation (LTP) and changes in the endogenous phosphorylation of a 40,000 dalton protein in the hippocampus in a calcium-dependent manner. In the present paper we report that 40 microM trifluoperazine (TFP), a phenothiazine that binds calmodulin and blocks its activity, inhibits LTP in the hippocampal slice. In addition, calmodulin stimulates and TFP inhibits the phosphorylation of the 40,000 dalton protein (as well as that of several other proteins) in a dose-dependent fashion.

Type

Journal article

Journal

Neurosci Lett

Publication Date

08/1980

Volume

19

Pages

103 - 108

Keywords

Animals, Calcium, Calmodulin, Evoked Potentials, Hippocampus, In Vitro Techniques, Nerve Tissue Proteins, Phosphorylation, Rats, Synapses, Synaptic Transmission, Trifluoperazine