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The regional and cellular distribution of four synaptic vesicle-associated proteins, synapsins Ia and Ib (Mr 86,000 and 80,000, collectively referred to as synapsin I) and proteins IIIa and IIIb (Mr 74,000 and 55,000, collectively referred to as protein III), has been compared in selected rat brain regions, using both radioimmunoassays and back-phosphorylation assays. Lesions of several neuronal populations in the basal ganglia (corticostriatal fibers, intrinsic striatal neurons, striatonigral fibers, nigrostriatal fibers) induced decreases in the levels of these various proteins that were highly correlated (r = 0.96-0.97). Moreover, the synaptic vesicle-associated phosphoproteins displayed a similar and widespread distribution throughout the CNS. This evidence for colocalization indicates that the majority of, and possibly all, CNS neurons and nerve terminals may contain both forms of synapsin I and both forms of protein III.

Type

Journal article

Journal

J Neurochem

Publication Date

10/1988

Volume

51

Pages

1214 - 1220

Keywords

Animals, Brain, Brain Chemistry, Cerebral Cortex, Corpus Striatum, Kainic Acid, Male, Nerve Tissue Proteins, Neuropeptides, Phosphoproteins, Phosphorylation, Radioimmunoassay, Rats, Rats, Inbred Strains, Substantia Nigra, Synapsins, Synaptic Vesicles, Tissue Distribution