BMedSci BM BS DM MRCPsych
Associate Professor and Clinical Senior Lecturer
- Honorary Consultant Psychiatrist
- Clinical Director NIHR CRN Thames Valley and South Midlands
- Deputy Director NIHR CLAHRC Oxford
- Clinical Lead Early Intervention Mental Health Network Oxford AHSN
early psychosis, neuroimmunology
My research is on the causes and treatment of psychotic illness.
Psychotic illnesses such as schizophrenia and bipolar disorder are serious mental illnesses of unknown cause. There is an urgent need to discover the basis of these illnesses, and to develop new treatments
I am exploring the neuro-immunological basis of psychotic disorders. We have described the prevalence of antibodies against the NMDA receptor, and other neuronal targets, in people with a first episode of psychosis. We are now setting up a clinical trial to see whether immunotherapy is an effective treatment for psychosis, in people with these antibodies
I run a joint psychiatry- neuroimmunology clinic with Dr Camilla Buckley at Oxford University Hospitals NHS Trust for treating people with psychosis and antibodies, run alongside Professor Angela Vincent's neuroimmunology laboratory. Together we collaborate with academic groups and clinicians from across the UK and internationally to advance our understanding of these disorders and to treat patients with the best evidence based treatments.
I am academic lead for the Early Intervention in psychosis service for Oxford Health NHS FT and am leading the evaluation and implementation of early intervention in psychosis services across the Thames Valley through the NIHR CLAHRC for Oxford and Oxford AHSN Early Intervention in Mental Health Network.
Disease-relevant autoantibodies in first episode schizophrenia.
Zandi MS. et al, (2011), J Neurol, 258, 686 - 688
Functional dysconnectivity of corticostriatal circuitry as a risk phenotype for psychosis.
Fornito A. et al, (2013), JAMA Psychiatry, 70, 1143 - 1151
Antibodies to the N-methyl-D-aspartate receptor and other synaptic proteins in psychosis
Deakin J. et al, (2014), Biological Psychiatry, 75, 284 - 291
Explicit and implicit facial affect recognition in manic and depressed States of bipolar disorder: a functional magnetic resonance imaging study.
Chen CH. et al, (2006), Biol Psychiatry, 59, 31 - 39
Emerging psychiatric syndromes associated with antivoltage-gated potassium channel complex antibodies.
Prüss H. and Lennox BR., (2016), J Neurol Neurosurg Psychiatry
Functional MRI of emotional memory in adolescent depression.
Holt RJ. et al, (2016), Dev Cogn Neurosci, 19, 31 - 41
N-Methyl-D-Aspartate Receptor Autoantibodies in Psychiatric Illness.
Zandi MS. et al, (2016), Biol Psychiatry, 79
Aberrant brain responses to emotionally valent words is normalised after cognitive behavioural therapy in female depressed adolescents.
Chuang JY. et al, (2016), J Affect Disord, 189, 54 - 61
Clinical relevance of serum antibodies to extracellular N-methyl-D-aspartate receptor epitopes.
Zandi MS. et al, (2015), J Neurol Neurosurg Psychiatry, 86, 708 - 713