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Department Seminar Series *Bonus* | Contexts and Confounders in Clinical Practice, in Wearables, and as a path to novel drug discovery

Professor Stephen Friend, 4YouandMe

Tuesday, 18 November 2025, 10.30am to 11.30am

Hosted by Professor Andrea Cipriani

Most clinical insights are based on static measures and aggregate insights. We are interested in the dynamic changes able to be tracked by smartphones and wearables - "personal digital health technologies". The more we focus at the n=one level the more awkward it seems to assume that a priori information should be borrowed directly from others. The talk will review past efforts on stress and pregnancy, current efforts on Bipolar disease with UK Bipolar, and emerging efforts on forecasting frailty using dynamic resilience. The last part of the lecture will discuss how rare clinical outliers can point the path to discovering new therapies.