Laura Winchester

D Phil

Alzheimer's Research UK Fellow

Athena Swan Departmental Lead
Senior Postdoctoral Researcher
DEMON (Deep Dementia Phenotyping Network) Biomarkers Working Group Lead

Research Interests

I am based in the informatics team working on dementia and Alzheimer's Disease in the Translational Neuroscience and Dementia Research Group. As a bioinformatician, I am interested in the application of large scale multi-omics data to better understand disease variants and therapeutics. My main focus is in using genomic and proteomic data analysis from Alzheimer’s Disease, Parkinson’s Disease and healthy population cohorts to develop new biomarkers and understand dementia mechanisms by applying integrative and machine learning methodologies.

Websites

Recent publications

The Relationship Between Isolated Hypertension with Brain Volumes in UK Biobank
Journal article

NEWBY D., (2022), Brain and Behavior
Validation of UK Biobank data for mental health outcomes: A pilot study using secondary care electronic health records.
Journal article

Li Z. et al, (2022), Int J Med Inform, 160
High Blood Pressure and Risk of Dementia: A Two-Sample Mendelian Randomization Study in the UK Biobank.
Journal article

Sproviero W. et al, (2021), Biol Psychiatry, 89, 817 - 824
Discovery and validation of plasma proteomic biomarkers relating to brain amyloid burden by SOMAscan assay.
Journal article

Shi L. et al, (2019), Alzheimers Dement, 15, 1478 - 1488
CSF1R inhibitor JNJ-40346527 attenuates microglial proliferation and neurodegeneration in P301S mice.
Journal article

Mancuso R. et al, (2019), Brain, 142, 3243 - 3264
Red blood cell indices and anaemia as causative factors for cognitive function deficits and for Alzheimer's disease.
Journal article

Winchester LM. et al, (2018), Genome Med, 10

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